期刊
JOURNAL OF DRUG TARGETING
卷 26, 期 5-6, 页码 398-406出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1061186X.2017.1419360
关键词
Liposome; calcium phosphate; lipid-coated calcium-phosphate nanoparticles; endosomal escape; reconstituted high-density lipoprotein; drug delivery
资金
- National Natural Science Foundation of China [81373351, 81573382, 81722043]
- Shanghai Science and Technology Committee [15540723700]
- Shanghai Municipal Education Commission and Shanghai Education Development Foundation [15SG14]
In recent years, lipid-coated calcium-phosphate (LCP) nanoparticle has been developed as a versatile platform for delivery of various therapeutics including gene, protein/peptide, chemotherapeutics and theranostic agents. The high endosomal escape, coupled with the ability to efficiently encapsulate phosphorylated drugs or prodrugs, make LCP become attractive vehicle for drug delivery. Additionally, the principle behind LCP formulation has also allowed rational design of LCP-derived nanoparticles (NPs) with other solid core or lipid membrane to overcome the various drug delivery barriers. Here, we briefly review the history of the development of LCP NPs, highlight the optimisations and modulations in the development process, and summarise the major applications of LCP NPs and LCP-derived NPs in drug delivery.
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