期刊
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
卷 42, 期 -, 页码 155-180出版社
ELSEVIER
DOI: 10.1016/j.jddst.2017.06.018
关键词
Protein delivery; Peptide delivery; Lipid formulation; Polymeric formulation; Nanocapsule; Nanoparticle; Liposome; Microemulsion
资金
- Xunta de Galicia (Competitive Reference Groups -FEDER Funds) [2014/043]
- TRANS-INT European Consortium from the European Union's Seventh Framework Programme for research, technological development and demonstration [281035]
- FPU program from the Ministry of Education, Culture and Sports, MECD, Spain [FPU13/02015]
- European Union's Horizon - Research and Innovation Framework Programme under the Marie Sklodowska - Curie Grant [642028]
Therapeutic proteins and peptides are very attractive from the pharmaceutical point of view due to their high potency and selectivity. Nonetheless, their instability and low bioavailability make their administration through non parenteral routes very difficult, a fact that hampers their efficient exploitation in therapeutics. Since the 70's, significant amount of research in the area of drug delivery and nanotechnology has been done with the final goal of overcoming those hurdles. In particular, biodegradable and biocompatible lipid and polymer-based nanocarriers have emerged as promising delivery platforms to enable the administration of proteins and peptides. This review provides an overview of the mostly explored nanotechnologies to date intended to produce lipidic and polymeric nanocarriers for protein/ peptide delivery. The basic principles of the different techniques are discussed, and the main factors involved in the drug association and release, are analyzed. Finally, a brief overview of the potential applications of these protein/peptide-loaded nanocarriers, highlighting the nanomedicines that have reached the market or the clinical development phase, is provided. (C) 2017 Elsevier B.V. All rights reserved.
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