A combination of Yiqiqubai granule and 308-nm excimer laser in treatment of segmental vitiligo: a prospective study of 233 patients

Objective: To study the effect of Yiqiqubai granule combined with 308-nm excimer laser treatment for segmental vitiligo (SV).Methods: A prospective research was performed in 233 patients with SV treated in Shanghai General Hospital from 11 February 2015 to 25 August 2016, they were divided into group A (n=75), group B (n=78) and group C (n=80) according to the random number table. Group A was treated with Yiqiqubai granule, group B treated with 308-nm excimer laser and group C treated with combined treatments. The treatment time lasts for 6 months. The clinical efficacy, color-reverse rate and quality of life of the three groups were assessed.Results: After treatment, the effective rate and markedly effective rate of group C (87.5%, 51.3%) were significantly higher than group A (74.7%, 42.7%) and group B (80.8%, 47.4%) (p<.05). Color-reverse rate of group C (66.517.6%) was much higher than group A (47.2 +/- 16.4%) and group B (49.9 +/- 24.2%) (p<.05). Significant differences were found among three groups after treatment in terms of embarrassment, social and work (p<.05).Conclusions: The combination of 308-nm excimer laser and Yiqiqubai granule in the treatment of SV has good clinical effect.