期刊
JOURNAL OF DERMATOLOGICAL TREATMENT
卷 30, 期 1, 页码 27-34出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09546634.2017.1364694
关键词
Patient-reported outcomes; Psoriasis Symptoms and Signs Diary; PSSD; psoriasis; validation
类别
资金
- Janssen Research & Development, LLC, Spring House, PA, USA
Purpose: The Psoriasis Symptoms and Signs Diary (PSSD) is a patient-reported instrument that assesses severity of six symptoms (itch, skin tightness, burning, stinging, and pain) and five signs (dryness, cracking, scaling, shedding/flaking, redness, and bleeding) of psoriasis. Materials and methods: PSSD symptoms and signs summary scores (range, 0-100) were derived based on individual item scores (0-10 [absent-worst imaginable]). Using Psoriasis Area and Severity Index [PASI], Investigator's Global Assessment [IGA] and Dermatology Life Quality Index [DLQI]) data from the NAVIGATE trial of patients with moderate-to-severe psoriasis, analyses were conducted to further validate the PSSD (7-day recall version) and establish criteria for clinically meaningful improvements (CMIs). Results: Mean PSSD symptoms and signs summary scores were 50.6 and 60.7, respectively, at baseline, with no major floor (score of 0) or ceiling (maximum score) effects. PSSD scores and changes in PSSD scores were highly correlated with PASI, IGA, and DLQI scores (most Spearman's correlation r's >= 0.4, all p < .001). A 2-grade improvement in IGA or an improvement of 75%-Conclusions: The PSSD possesses strong psychometric properties and is suitable for use as a measure of disease severity in clinical studies of patients with moderate-to-severe psoriasis.
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