Developmental defects of enamel and dental caries in the primary dentition: A systematic review and meta-analysis

Objectives: This systematic review and meta-analysis evaluated the association between developmental defects of enamel and dental caries in the primary dentition. Sources: Electronic searches were performed in PubMed, Web of Knowledge, Scopus and Scielo for the identification of relevant studies. Study selection: Observational studies that examined the association between developmental defects of enamel and dental caries in the deciduous dentition were included. Additionally, meta-analysis, funnel plots and sensitivity analysis were employed to synthesize the available evidence. Multivariable meta-regression analysis was performed to explore heterogeneity among studies. Data: A total of 318 articles were identified in the electronic searches. Of those, 16 studies were included in the meta-analysis. Pooled estimates revealed that children with developmental defects of enamel had higher odds of having dental caries (OR 3.32; 95% CI 2.41-4.57), with high heterogeneity between studies (I-2 80%). Methodological characteristic of the studies, such as where it was conducted, the examined teeth and the quality of the study explained about 30% of the variability. Concerning type of defect, children with hypoplasia and diffuse opacities had higher odds of having dental caries (OR 4.28; 95% CI 2.24-8.15; OR1.42; 95% CI 1.15-1.76, respectively). Conclusions: This systematic review and meta-analysis demonstrates a clear association between developmental defects of enamel and dental caries in the primary dentition. (C) 2017 Elsevier Ltd. All rights reserved.