期刊
JOURNAL OF DENTISTRY
卷 67, 期 -, 页码 88-93出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jdent.2017.10.001
关键词
Biofilms; Dental caries susceptibility; Dental pellicle; Dentifrices; Oral health; Risk factor
资金
- National Key Research and Development Program of China [2016YFC1102700]
- National Natural Science Foundation of China [81372889, 81600858, 81430011]
Objectives: To evaluate the effects of 8% arginine-containing toothpaste on the dental plaque of no caries (NC) and high caries (HC) individuals in situ. Methods: 6 no caries (DMFT = 0) and 6 high caries (DMFT = 6) individuals wearing a self-developed in situ dental plaque acquisition device were involved in a randomized double-blinded crossover study for 6 weeks: including lead-in (1 week), arginine-free (2 weeks), washout (1 week) and arginine-active (2 weeks) stages. The in situ plaque samples were collected at the endpoint of arginine-free and arginine-active stages and subjected to lactic acid production, metabolic activity, live/dead bacteria ratio and total biofilm biomass detections. Results: The arginine-containing dentifrice reduced lactic acid production significantly in both the NC and HC groups, while the inhibitory abilities in the HC group were stronger than that in the NC group. In addition, the arginine-containing dentifrice didn't significantly decrease the metabolic activity, live/dead bacteria ratio and total biofilm biomass in either the NC or the HC group. Conclusions: Arginine-containing toothpaste can significantly reduce the lactic acid production from the in situ plaques to a low level without changing the metabolic activity, live/dead bacteria ratio and total biofilm biomass through a critical clinical randomized double-blinded crossover study. Clinical significance: Arginine is a potential ecological prevention and control agent for dental caries. Meanwhile, the in situ model is an easy and pragmatic way to evaluate oral hygiene products.
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