期刊
PEPTIDE SCIENCE
卷 112, 期 3, 页码 -出版社
WILEY
DOI: 10.1002/pep2.24141
关键词
antimicrobial peptides; pathogenic microorganisms; Synoeca surinama
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
- Fundacao de Apoio a Pesquisa do Distrito Federal
- Fundacao de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do Estado de Mato Grosso do Sul
The rising number of multidrug-resistant microorganisms has triggered interest in the prospection of biocompounds with antimicrobial activities. Synoeca-MP consists of an antimicrobial peptide (AMP) classified as a mastoparan, which was isolated from the venom of Synoeca surinama, a social wasp. Synoeca-MP presented a potent antimicrobial activity, with values of MIC50 and MIC90 against methicillin-resistant Staphylococcus aureus-MRSA (1.9 and 2.2 mu M), Escherichia coli ESBL (2.0 and 2,1 mu M), vancomycin-resistant Enterococcus faecalis (8.3 and 17.1 mu M), Pseudomonas aeruginosa metallo-ss-lactamase (5.2 and 5.9 mu M), and Klebsiella pneumoniae KPC (3.5 and 4.7 mu M). Synoeca-MP was also tested against six Candida species, with MICs varying from 10 to 40 mu M. Moreover, the structural prediction for Synoeca-MP demonstrated a cationic alpha-helix capable of interacting with in silico membranes and low hemolytic activity. Due to its antimicrobial activity, synoeca-MP shows potential as an adjuvant to antibiotics and antifungals commonly used in antibiotic therapies.
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