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Neurotoxicities associated with checkpoint inhibitors: Two case reports and a review of the literature

期刊

CLINICAL CASE REPORTS
卷 8, 期 1, 页码 24-32

出版社

WILEY
DOI: 10.1002/ccr3.2534

关键词

aseptic meningitis; checkpoint inhibitor; encephalitis; ipilimumab; neurotoxicity; nivolumab

资金

  1. Intramural Research Program of the Center for Cancer Research, NCI, National Institutes of Health
  2. NATIONAL CANCER INSTITUTE [ZIABC011351, ZIEBC011384] Funding Source: NIH RePORTER

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We report a case of nivolumab-induced delayed-onset aseptic meningitis and a case of limbic encephalitis and peripheral nerve palsy with toxicity relapse 6 months after initial presentation. The atypical presentations contribute to our knowledge of these rare events and reinforce the necessity for vigilant monitoring and a multidisciplinary treatment approach.

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