期刊
JOURNAL OF CYSTIC FIBROSIS
卷 16, 期 2, 页码 214-221出版社
ELSEVIER
DOI: 10.1016/j.jcf.2016.10.012
关键词
Pseudomonas aeruginosa; Glutathione sulfonamide; Allantoin; Neutrophil; Neutrophil elastase; Myeloperoxidase
资金
- Canterbury Medical Research Foundation New Zealand [14/06]
- Health Research Council of New Zealand [15/333]
- National Health and Medical Research Council, Australia [403911, 458513, 1002035, 1102590]
- Cystic Fibrosis Foundation, USA [CFFT SLY04A0, STICK09A0]
- Cystic Fibrosis Australia [1021316]
- National Health and Medical Research Council of Australia [1102590] Funding Source: NHMRC
Background: In cystic fibrosis (CF) there is an urgent need for earlier diagnosis of pulmonary infections and inflammation using blood-and urine based biomarkers. Methods: Using mass spectrometry, oxidation products of glutathione and uric acid were measured in matched samples of bronchoalveolar lavage (BAL), serum and urine from 36 infants and children with CF, and related to markers of neutrophilic inflammation and infection in BAL. Results: Oxidation products of glutathione (glutathione sulfonamide, GSA) and uric acid (allantoin), were elevated in BAL of children with pulmonary infections with Pseudomonas aeruginosa (PsA) compared to those without (p < 0.05) and correlated with other markers of neutrophilic inflammation. Serum GSA was significantly elevated in children with PsA infections (p < 0.01). Urinary GSA correlated with pulmonary GSA (r = 0.42, p < 0.05) and markers of neutrophilic inflammation. Conclusions: This proof-of-concept study demonstrates that urinary GSA but not allantoin shows promise as a non-invasive marker of neutrophilic inflammation in early CF lung disease. (C) 2016 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据