期刊
THERANOSTICS
卷 10, 期 2, 页码 841-855出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.40715
关键词
iridium oxide/manganese dioxide; multimodal imaging; photothermal/photodynamic therapy; biomineralization; nanomedicine
资金
- Science and Technology Commission of Shanghai Municipality [16410723700]
- National Science Foundation for Young Scientists of China [81702831]
- Biomedical Textile Materials 111 Project of the Ministry of Education of China [B07024]
- UK-China Joint Laboratory for Therapeutic Textiles (Donghua University)
The hypoxia of the tumor microenvironment (TME) often hinders the effectiveness of cancer treatments, especially O-2-dependent photodynamic therapy (PDT). Methods: An integrated iridium oxide (IrO2)-manganese dioxide (MnO2) nanotheranostic agent was fabricated through bovine serum albumin (BSA)-based biomineralization of Ir3+ and Mn2+. BSA was first covalently modified with chlorin e6 (Ce6), and used to fabricate multifunctional BSA-Ce6@IrO2/MnO2 nanoparticles (NPs) for computed X-ray tomography (CT) and photoacoustic (PA) imaging-guided PDT and photothermal (PTT) therapy of cancer. Extensive in vitro and in vivo studies were performed. Results: The theranostic agent produced can relieve tumor hypoxia by the decomposition of endogenous H2O2 in cancer cells to oxygen. The oxygen generated can be exploited for improved PDT. Paramagnetic Mn2+ released from the NPs in the acidic TME permits magnetic resonance imaging (MRI) to be performed. The exceptional photothermal conversion efficiency (65.3%) and high X-ray absorption coefficient of IrO2 further endow the NPs with the ability to be used in computed CT and PA imaging. Extensive antitumor studies demonstrated that the BSA-Ce6@IrO2/MnO2 nanoplatform inhibits cancer cell growth, particularly after combined PTT and PDT. Systematic in vivo biosafety evaluations confirmed the high biocompatibility of the nanoplatform. Conclusion: This work not only provides a novel strategy for designing albumin-based nanohybrids for theranostic applications but also provides a facile approach for extending the biomedical applications of iridium-based materials.
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