期刊
PHYSICAL BIOLOGY
卷 17, 期 1, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1478-3975/ab4fbc
关键词
mRNA translation; gene expression; modeling; finite resources; resource competition
资金
- Fondecyt Iniciacion [11161046]
The number of ribosomes in a cell is considered as limiting, and gene expression is thus largely determined by their cellular concentration. In this work we develop a toy model to study the trade-off between the ribosomal supply and the demand of the translation machinery, dictated by the composition of the transcript pool. Our equilibrium framework is useful to highlight qualitative behaviours and new means of gene expression regulation determined by the fine balance of this trade-off. We also speculate on the possible impact of these mechanisms on cellular physiology.
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