期刊
MOLECULAR & CELLULAR ONCOLOGY
卷 7, 期 1, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2019.1699375
关键词
Ferroptosis; Hippo pathway; transcriptional coactivator with PDZ-binding motif (TAZ); Yes-associated protein 1 (YAP1); NADPH Oxidase 4 (NOX4); Renal Cell Carcinoma; Ovarian Cancer; Erastin; Epithelial Membrane Protein 1 (EMP1); Angiopoietin-Like 4 (ANGPTL4); NADPH Oxidase 2 (NOX2)
类别
资金
- Foundation for the National Institutes of Health [1R01NS111588, 1R01GM124062]
- U.S. Department of Defense [W81XWH-17-1-0143, W81XWH-19-1-0842, W81XWH-15-1-0486]
Ferroptosis a novel form of programmed cell death. We found that the ferroptosis sensitivity in renal and ovarian cancers are regulated by cell density through TAZ-EMP1-NOX4 and TAZ-ANGPTL4-NOX2 pathway, respectively. These findings reveal TAZ as a novel genetic determinant of ferroptosis. Triggering ferroptosis may have therapeutic potential for TAZ-activated tumors.
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