Managing sepsis: Electronic recognition, rapid response teams, and standardized care save lives

Purpose: Sepsis can lead to poor outcomes when treatment is delayed or inadequate. The purpose of this study was to evaluate outcomes after initiation of a hospital-wide sepsis alert program. Materials and methods: Retrospective review of patients >= 18 years treated for sepsis. Results: Therewere 3917 sepsis admissions: 1929 admissions before, and 1988 in the after phase. Mean age (57.3 vs. 57.1, p=0.94) and Charlson Comorbidity Scores (2.52 vs. 2.47, p= 0.35) were similar between groups. Multivariable analyses identified significant reductions in the after phase for odds of death (OR 0.62, 95% CI 0.390.99, p = 0.046), mean intensive care unit LOS (2.12 days before, 95% CI 1.97, 2.34; 1.95 days after, 95% CI 1.75, 2.06; p b 0.001), mean overall hospital LOS (11.7 days before, 95% CI 10.9, 12.7 days; 9.9 days after, 95% CI 9.3, 10.6 days, p < 0.001), odds ofmechanical ventilation use (OR 0.62, 95% CI 0.39, 0.99, p=0.007), and total charges with a savings of $7159 per sepsis admission (p = 0.036). There was no reduction in vasopressor use (OR 0.89, 95% CI 0.75, 0.1.06, p= 0.18). Conclusion: A hospital- wide program utilizing electronic recognition and RRT intervention resulted in improved outcomes in patients with sepsis. (C) 2017 Elsevier Inc. All rights reserved.