期刊
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
卷 20, 期 -, 页码 53-57出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ctro.2019.05.002
关键词
Radiation; Mouse model; Lymph node; Metastasis; Abscopal effect
资金
- JSPS KAKENHI [17H00865, 17K20077, 18H03544]
- Grants-in-Aid for Scientific Research [18H03544, 17K20077, 17H00865] Funding Source: KAKEN
Utilizing mice with swollen lymph nodes, we succeeded in irradiating individual metastatic lymph nodes through a hole in a lead shield. This system enabled us to increase the radiation dose to >8 Gy (the lethal dose for total-body irradiation) and evaluate both direct and abscopal antitumor effects. (C) 2019 The Authors. Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.
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