期刊
CHEMICAL COMMUNICATIONS
卷 56, 期 1, 页码 94-97出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc07666b
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资金
- Centre National de la Recherche Scientifique
- Universite de Toulouse
- European Commission [Gold3Cat-799606]
Cycling between Au(i) and Au(iii) is challenging, so gold-catalyzed cross-couplings are rare. The (MeDalphos)AuCl complex, which we showed was prone to undergo oxidative addition, is reported here to efficiently catalyze the C-N coupling of aryl iodides and amines. The transformation does not require an external oxidant or a directing group. It is robust and works with a wide scope of aryl iodides and N-nucleophiles under mild conditions. Mechanistic studies, including the NMR and MS characterization of a key aryl amido Au(iii) complex, strongly support a 2e redox cycle in which oxidative addition precedes transmetalation and reductive elimination is the rate-determining step.
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