期刊
JOURNAL OF CONTROLLED RELEASE
卷 266, 期 -, 页码 140-155出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2017.09.031
关键词
Gel; Liposome; Micelle; Dendrimer; Lipid nanocapsules; Solid nanocapsules; Polymeric nanocapsules; Fullerene; Health application; In vivo
资金
- EuroNanoMed-II
- Fondation ARC pour le Recherche sur le Cancer
- Ligue Contre le Cancer (Comite du Maine et Loire)
The combination of pharmaceutical technologies can be a wise choice for developing innovative therapeutic strategies. The association of nanocarriers and gels provides new therapeutic possibilities due to the combined properties of the two technologies. Gels support the nanocarriers, localize their administration to the target tissue, and sustain their release. In addition to the properties afforded by the gel, nanocarriers can provide additional drug sustained release or different pharmacokinetic and biodistribution profiles than those from nanocarriers administered by the conventional route to improve the drug therapeutic index. This review focuses on recent (over the last ten years) in vivo data showing the advances and advantages of using nanocarrier-loaded gels. Liposomes, micelles, liquid and solid lipid nanocapsules, polymeric nanoparticles, dendrimers, and fullerenes are all nanotechnologies which have been recently assessed for medical applications, such as cancer therapy, the treatment of cutaneous and infectious diseases, anesthesia, the administration of antidepressants, and the treatment of unexpected diseases, such as alopecia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据