期刊
JOURNAL OF CONTROLLED RELEASE
卷 261, 期 -, 页码 318-336出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2017.06.020
关键词
Anti-adhesion; Biomimetic scaffold; Electrospun fibers; Biomaterials
资金
- National Natural Science Foundation of China [51373112]
- Social Development Project of Yangzhou Key Research Program [YZ2015070]
- Jiangsu Provincial Special Program of Medical Science [BL2012004]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI)
- Portugal 2020
- Portuguese funds through FCT - Fundacao para a Ciencia e a Tecnologia/Ministerio da Ciencia, Tecnologia e Inovacao [POCI-01-0145-FEDER-007274]
Adhesion is one of the most common postsurgical complications, occurring simultaneously as the damaged tissue heals. Accompanied by symptoms such as inflammation, pain and even dyskinesia in particular circumstances, tissue adhesion has substantially compromised the quality of life of patients. Instead of passive treatment, which involves high cost and prolonged hospital stay, active intervention to prevent the adhesion from happening has been accepted as the optimized strategy against this complication. Herein, this paper will cover not only the mechanism of adhesion forming, but also the biomaterials and medicines used in its prevention. Apart from acting as a direct barrier, biomaterials also show promising anti-adhesive bioactivity though their intrinsic physical and chemical are still not completely unveiled. Considering the diversity of human tissue organization, it is imperative that various biomaterials in combination with specific medicine could be tuned to fit the microenvironment of targeted tissues. With the illustration of different adhesion mechanism and solutions, we hope this review can become a beacon and further inspires the development of anti-adhesion biomedicines.
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