期刊
JOURNAL OF CONTROLLED RELEASE
卷 268, 期 -, 页码 343-351出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2017.10.013
关键词
Enteric coating; Supercritical impregnation; Oral drug delivery; Microtechnology
资金
- Danish National Research Foundation [DNRF122]
- Villum Fonden [9301]
- Danish Research Council for Technology and Production (FTP) [DFF 4004-00120B]
- Villum Fonden [00009301] Funding Source: researchfish
This work explores the potential of polymeric micrometer sized devices (microcontainers) as oral drug delivery systems (DDS). Arrays of detachable microcontainers (D-MCs) were fabricated on a sacrificial layer to improve the handling and facilitate the collection of individual D-MCs. A model drug, ketoprofen, was loaded into the microcontainers using supercritical CO2 impregnation, followed by deposition of an enteric coating to protect the drug from the harsh gastric environment and to provide a fast release in the intestine. In vitro, in vivo and ex vivo studies were performed to assess the viability of the D-MCs as oral DDS. D-MCs improved the relative oral bioavailability by 180% within 4 h, and increased the absorption rate by 2.4 times compared to the control. This work represents a significant step forward in the translation of these devices from laboratory to clinic.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据