期刊
JOURNAL OF CONTROLLED RELEASE
卷 263, 期 -, 页码 185-191出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2017.01.016
关键词
Nanomedicine; Cell membrane coating; Detoxification; Antibiotic delivery; Staph infection
资金
- National Institutes of Health [R01CA200574, R01EY025947]
We reported an erythrocyte membrane-coated nanogel (RBC-nanogel) system with combinatorial antivirulence and responsive antibiotic delivery for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection. RBC membrane was coated onto the nanogel via a membrane vesicle templated in situ gelation process, whereas the redox-responsiveness was achieved by using a disulfide bond-based crosslinker. We demonstrated that the RBC-nanogels effectively neutralized MRSA-associated toxins in extracellular environment and the toxin neutralization in turn promoted bacterial uptake by macrophages. In intracellular reducing environment, the RBC-nanogels showed an accelerated drug release profile, which resulted in more effective bacterial inhibition. When added to the macrophages infected with intracellular MRSA bacteria, the RBC-nanogels significantly inhibited bacterial growth compared to free antibiotics and non-responsive nanogel counterparts. These results indicate the great potential of the RBC-nanogel system as a new and effective antimicrobial agent against MRSA infection. (C) 2017 Elsevier B.V. All rights reserved.
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