期刊
JOURNAL OF CONTROLLED RELEASE
卷 255, 期 -, 页码 154-163出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2017.04.001
关键词
Cellulose nanocrystal; Gold nanorod; CD-PGEA; Combined therapy; Photoacoustic imaging
资金
- National Key Research and Development Program of China [2016YFA0201501]
- National Natural Science Foundation of China [51325304, 51373017, 51473014, 51521062]
- Fundamental Research Funds for the Central Universities [JD1618]
- Higher Education and High-quality and World-class Universities [PY201603]
The development of new hetero-nanostructures for multifunctional applications in cancer therapy has attracted widespread attention. In this work, we put forward a facile approach to synthesize multifunctional hetero-nanostructures of cellulose nanocrystal (CNC)-gold nanoparticle hybrids wrapped with low-toxic hydroxyl-rich polycations to integrate versatile functions for effective cancer therapy. Biocompatible CNCs with the superior rod-like morphology for high cellular uptake were employed as substrates to flexibly load spherical gold nanoparticles (Au NPs) or gold nanorods (Au NRs) through gold-thiolate bonds, producing hetero-layered nanohybrids of CNC-Au NPs or CNC-Au NRs. Profound hydroxyl-rich cationic gene carrier, CD-PGEA (comprising beta-cyclodextrin cores and ethanolamine-functionalized poly(glycidyl methacrylate) arms), was then assembled onto the surface of CNC-Au nanohybrids through host-guest interaction and gold-thiolate bonds, where PEG was employed as the intermediate and spacer. The resultant CNC-Au-PGEA hetero-nanostructures exhibited excellent performances as gene carriers. Furthermore, CNC-Au NR-PGEA comprising Au NRs demonstrated favorable optical absorption properties and were validated for photoacoustic imaging and combined photothermal/gene therapy with considerable antitumor effects. The present work provided a flexible strategy for the construction of new multifunctional hetero-nanostructures with high antitumor efficacy.
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