期刊
JOURNAL OF CONTROLLED RELEASE
卷 254, 期 -, 页码 1-9出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2017.03.036
关键词
Polymer-drug conjugate; Boron neutron capture therapy; Drug delivery system; Tumor penetration; Sodium borocapate
资金
- Japan Society for the Promotion of Science (JSPS) [P13042]
- Center of Innovation (COI) Program from Japan Science and Technology Agency (JST)
- Japan Agency for Medical Research and Development (AMED) [16cm0106202h0001]
- Grants-in-Aid for Scientific Research [16K15104, 25293267, 15H04635, 16F16058, 16H03179, 16F16407] Funding Source: KAKEN
Boron neutron capture therapy is a promising tumor treatment method, though its wide application has been limited due to the poor tumor selectivity and intracellular delivery of B-10-compounds. Here, block copolymerboron cluster conjugate based on the clinically used sodium borocaptate (BSH) and poly(ethylene glycol)-b-poly (glutamic acid) copolymer have been developed for effectively penetrating tumor tissues and homogeneously delivering the boron clusters into cancer cells towards safe and efficient boron neutron capture therapy. The PEGylated block copolymer-boron cluster (BSH) conjugate has demonstrated significant higher cellular uptake and tumor accumulation when compared to the non-PEGylated formulations and BSH. Moreover, the enhanced delivery to tumors of the conjugates, as well as their superior intratumoral penetration, which facilitated reaching the intracellular space of most cells in tumors, allowed the effective ablation of tumors after neutron irradiation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据