期刊
RSC ADVANCES
卷 10, 期 1, 页码 10-20出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra09021e
关键词
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资金
- National Natural Science Foundation of China [31530026, 31900981, 31871005]
- Chinese Academy of Sciences [YJKYYQ20180048]
- Key Research Program of Frontier Sciences, CAS [QYZDY-SSW-SMC013]
- National Key Research and Development Program of China [2017YFA0205501]
- Youth Innovation Promotion Association CAS [2019093]
- Strategic Priority Research Program [XDPB29040101]
Nanozymes, a type of nanomaterial with intrinsic enzyme-like activities, have emerged as a promising tool for disease theranostics. As a type of artificial enzyme mimic, nanozymes can overcome the shortcomings of natural enzymes, including high cost, low stability, and difficulty in storage when they are used in disease diagnosis. Moreover, the multi-enzymatic activity of nanozymes can regulate the level of reactive oxygen species (ROS) in various cells. For example, superoxide dismutase (SOD) and catalase (CAT) activity can be used to scavenge ROS, and peroxidase (POD) and oxidase (OXD) activity can be used to generate ROS. In this review, we summarize recent progress on the strategies and applications of nanozyme-based disease theranostics. In addition, we address the opportunities and challenges of nanozyme-based catalytic theranostics in the near future.
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