期刊
ACS APPLIED BIO MATERIALS
卷 3, 期 1, 页码 292-301出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.9b00817
关键词
vascularization; core-shell robocasting; microstructure tailoring; controlled ion release; single-phase bioceramics
资金
- National Key Research and Development Program of China [2017YFE0117700, 2018YC1105401]
- Science and Technology Department of Zhejiang Province Foundation [LGF18E020001, 2017C33141]
- National Key Research and Development Program of Zhejiang Province [2019C03027]
- National Natural Science Foundation of China [81772311, 81871775]
The inorganic powder slurry extrusion printing technique known as robocasting is an interesting method to fabricate complex porous architectures whereby feedstocks containing organic binders and powders are printed and the resulting scaffolds are subjected to sintering. A major limiting factor of this technique is the simultaneous tailoring of vascularization efficacy and osteogenic activity, usually done by adding the secondary phase in the organic slurry before the writing step. Mechanical mixing of biphasic powders is required to avoid compromising the biological performance and physical defects caused by significantly different physicochemical properties. This study addresses this issue by developing a selective ion doping and microstructure tuning for the production of bioceramic scaffolds with a binozzle robocasting process. Different metal ions (Sr2+, Mg2+) were doped into wollastonite (CaSiO3; CSi) powders considering the mechanical stability and bioactive enhancement of the bioceramic scaffolds. Subsequently, the Mg-doped CSi slurries were used as shell-nozzle feedstocks added with 5, 10, and 15 mu m diameter polystyrene microbeads that allowed shell-layer micropore production in pore struts during sintering. Finally, the most promising pore-strut microstructures and mechanical evolution of scaffolds were evaluated, and especially the enhanced fibrovascularization potential was confirmed in dorsal muscle embedding model in rabbits. This study may open an avenue to designing multiproperty-tuned macro- and microporous bioceramics for bone regenerative medicine, especially in challenging bone defect conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据