期刊
WORLD JOURNAL OF CARDIOLOGY
卷 12, 期 1, 页码 26-34出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4330/wjc.v12.i1.26
关键词
Radial artery; Cannulation; Spasm; Nitric oxide; Vasodilation; Nanoporous material
资金
- European Social Fund
- Scottish Funding Council as part of Developing Scotland's Workforce in the Scotland 2014-2020 European Structural and Investment Fund Programme
Percutaneous coronary intervention for the treatment of coronary artery disease is most commonly performed in the UK through the radial artery, as this is safer than the femoral approach. However, despite improvements in technology and techniques, complications can occur. The most common complication, arterial spasm, can cause intense pain and, in some cases, procedural failure. The incidence of spasm is dependent on several variables, including operator experience, artery size, and equipment used. An anti-spasmolytic cocktail can be applied to reduce spasm, which usually includes an exogenous nitric oxide (NO) donor (glyceryl trinitrate). NO is an endogenous local vasodilator and therefore is a potential target for anti-spasm intervention. However, systemic administration can result in unwanted side-effects, such as hypotension. A method that adopts local delivery of NO might be advantageous. This review article describes the mechanisms involved in radial artery spasm, discusses the advantages and disadvantages of current strategies to reduce spasm, and highlight the potential of NO-loaded nanoporous materials for use in this setting.
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