期刊
NATURE REVIEWS CANCER
卷 20, 期 3, 页码 174-186出版社
NATURE PORTFOLIO
DOI: 10.1038/s41568-019-0238-1
关键词
-
类别
资金
- Cold Spring Harbor Laboratory and Northwell Health Affiliation
- Francis Crick Institute
- Cancer Research UK [C219/A23522]
- UK Medical Research Council [MR/PO18823/1]
- Wellcome Trust [206439/Z/17/Z]
- EPSRC
- AstraZeneca
- Martin and Concetta Greenberg Pancreatic Cancer Institute
- In Vino Vita Institutional Pilot Award
- Pennsylvania's Department of Health Health Research Formula Funds
- Greenfield Foundation
- Fifth District AHEPA Cancer Research Foundation
- US National Institutes of Health (NIH)/National Cancer Institute (NCI) [R21-CA231252, R01-CA232256, CA06927]
- NIH/NCI [U01 CA199315-04]
- Thompson Family Foundation
- Stand Up To Cancer-Cancer Research UK-Lustgarten Foundation Pancreatic Cancer Dream Team Research Grant [SU2C-AACR-DT-20-16]
- Georg-Speyer-Haus
- LOEWE Center Frankfurt Cancer Institute - Hessen State Ministry for Higher Education, Research and the Arts [III L 5 -519/03/03.001 -(0015)]
- Deutsche Forschungsgemeinschaft [FOR2438: Gr1916/11-1]
- NCI [R01CA157490, R01CA188048, P01CA117969, R35CA232124]
- Pancreatic Cancer Action Network [17-85-HING]
- US Department of Defense BCRP Investigator Award [W81XWH-14-1-0240]
- Starr Cancer Consortium [I7-A718]
- National Cancer Institute [R35-CA197743, R01-CA208205, U01-CA224173]
- National Foundation for Cancer Research
- Advanced Medical Research Foundation
- Ellison Foundation
- Jane's Trust Foundation
- National Cancer Institute Cold Spring Harbor Laboratory Cancer Center [P30CA045508]
- Cancer Research UK Institute Award [A19258]
- NIH [R01CA232256, R01CA174746]
- Lustgarten Foundation
- SU2C
- Liddy Shriver Sarcoma Alliance (ImmunoSarc grant)
- Sarcoma Alliance for Research through Collaboration (SARC)
- Fondazione Enrico Pallazzo [18-MSSM-0302]
- Israel Science Foundation [401/17, 1384/1]
- European Research Council [754320]
- Laura Gurwin Flug Family Fund
- Comisaroff Family Trust
- American Cancer Society Research Scholar Grant [132898-RSG-18-142-01-CSM]
- US Army Medical Research Acquisition Activity
- Office of the Assistant Secretary of Defense for Health Affairs, through the Breast Cancer Research Program [W81XWH-16-1-0728]
- American Foundation for Urological Disease
- CaPCURE award
- California Breast Cancer Research Program [14OB-0165]
- Cold Spring Harbor Labor-atory Association
- V Foundation
- Guy's and St Thomas' NHS Foundation Trust Biomedical Research Centre [IS -BRC-1215-20006]
- National Institutes of Health Research (NIHR) [IS-BRC-1215-20006] Funding Source: National Institutes of Health Research (NIHR)
- European Research Council (ERC) [754320] Funding Source: European Research Council (ERC)
This Consensus Statement highlights the importance of cancer-associated fibroblasts in cancer biology and progression, and issues a call to action for all cancer researchers to standardize assays and report metadata in studies of cancer-associated fibroblasts to advance our understanding of this important cell type in the tumour microenvironment. Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding of the origin of CAFs and heterogeneity in CAF function, with it being desirable to retain some antitumorigenic functions. On the basis of a meeting of experts in the field of CAF biology, we summarize in this Consensus Statement our current knowledge and present a framework for advancing our understanding of this critical cell type within the tumour microenvironment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据