期刊
NATURE REVIEWS IMMUNOLOGY
卷 20, 期 5, 页码 294-307出版社
NATURE PORTFOLIO
DOI: 10.1038/s41577-019-0257-x
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资金
- Ministry of Education and Science of the Russian Federation [14.W03. 31.0005]
- Russian Science Foundation [19-14-00317]
- Russian Science Foundation [19-14-00317] Funding Source: Russian Science Foundation
This Review discusses the various ways in which B cells, plasma cells and antibodies shape the immune response in cancer. B cells can have both protumour and antitumour roles, and the authors discuss the potential of targeting these cells for therapy. Recent data show that B cells and plasma cells located in tumours or in tumour-draining lymph nodes can have important roles in shaping antitumour immune responses. In tumour-associated tertiary lymphoid structures, T cells and B cells interact and undergo cooperative selection, specialization and clonal expansion. Importantly, B cells can present cognate tumour-derived antigens to T cells, with the functional consequences of such interactions being shaped by the B cell phenotype. Furthermore, the isotype and specificity of the antibodies produced by plasma cells can drive distinct immune responses. Here we summarize our current knowledge of the roles of B cells and antibodies in the tumour microenvironment. Moreover, we discuss the potential of using immunoglobulin repertoires as a source of tumour-specific receptors for immunotherapy or as biomarkers to predict the efficacy of immunotherapeutic interventions.
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