期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 527, 期 1, 页码 225-235出版社
WILEY
DOI: 10.1002/cne.24172
关键词
cell fate; retinal ganglion cells; transcription factors; RRID: AB_2301417; RRID: AB_882455; RRID: AB_10615604; RRID: AB_11143446; RRID: AB_2167511; RRID: AB_2313614; RRID: AB_1608077; RRID: AB_231491
资金
- NIH [R01 E4014689]
- CIRM Postdoctoral Fellowships [TG201157]
- CIRM Facilities [FA1-00617-1]
Retinal ganglion cells (RGCs) are tasked with transmitting all light information from the eye to the retinal recipient areas of the brain. RGCs can be classified into many different types by morphology, gene expression, axonal projections, and functional responses to different light stimuli. Ultimately, these classification systems should be unified into an all-encompassing taxonomy. Toward that end, we show here that nearly all RGCs express either Islet-2 (Isl2), Tbr2, or a combination of Satb1 and Satb2. We present gene expression data supporting the hypothesis that Satb1 and Satb2 are expressed in ON-OFF direction-selective (DS) RGCs, complementing our previous work demonstrating that RGCs that express Isl2 and Tbr2 are non-DS and non-image-forming, respectively. Expression of these transcription factors emerges at distinct embryonic ages and only in postmitotic cells. Finally, we demonstrate that these transcription factor-defined RGC classes are born throughout RGC genesis.
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