期刊
DERMATOLOGY
卷 230, 期 1, 页码 27-33出版社
KARGER
DOI: 10.1159/000365390
关键词
DLQI; MCID; Responsiveness; Minimum clinically important difference; Skin disease
类别
资金
- Department of Dermatology and Wound Healing, Cardiff University
Aims: To determine the minimal clinically important difference (MCID) of the Dermatology Life Quality Index (DLQI) and its responsiveness to change in inflammatory skin diseases. Methods: A longitudinal study: at stage 1, patients completed the DLQI and a disease severity global question; at stage 2, a global rating of change in quality of life (QoL; Global Rating of Change Questionnaire, GRCQ) was added and used as an anchor to measure the MCID of the DLQI. Results: 192 patients completed stage 1 and 107 completed stage 2. The mean DLQI score at stage 1 was 9.8 and 7.4 at stage 2 with a mean change of 2.4 (p <0.0001). 31 patients experienced a 'small change' in their QoL (+/- 3 and +/- 2) on the GRCQ. The mean corresponding change in DLQI scores was 3.3, which is regarded as the approximate MCID. Conclusions: Previous estimates of the MCID of the DLQI have varied from 3 to 5. Although this study demonstrated a MCID of 3.3, we recommend that the MCID in inflammatory skin diseases should be 4. (C) 2015 S. Karger AG, Basel
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