期刊
THERANOSTICS
卷 10, 期 5, 页码 2260-2272出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.41317
关键词
A single laser; semiconducting polymers; aggregation-induced emission fluorogens; fluorescence resonance energy transfer; dual photothermal therapy
资金
- National Natural Science Foundation of China [21788102, 21525523, 21722507, 21874121, 21974128]
- National Key RAMP
- D Program of China [2017YFA0208000]
Semiconducting polymers (SPs)-based dual photothermal therapy (PTT) obtained better therapeutic effect than single PTT due to its higher photothermal conversion efficiency. However, most dual PTT need to use two lasers for heat generation, which brings about inconvenience and limitation to the experimental operations. Herein, we report the development of nanococktail nanomaterials (DTPR) with 808 nm-activated image-guided dual photothermal properties for optimized cancer therapy. Methods: In this work, we co-encapsulated AIEgens (TPA-BDTO, T) and SPs (PDPPP, P) by using maleimide terminated amphiphilic polymer (DSPE-PEG(2000)-Mal, D), then further conjugated the targeting ligands (RGD, R) through click reaction. Finally, such dual PTT nanococktail (termed as DTPR) was constructed. Results: Once DTPR upon irradiation with 808 nm laser, near-infrared fluorescence from T could be partially converted into thermal energy through fluorescence resonance energy transfer (FRET) between T and P, coupling with the original heat energy generated by the photothermal agent P itself, thus resulting in image-guided dual PTT. The photothermal conversion efficiency of DTPR reached 60.3% (dual PTT), much higher as compared to its inherent photothermal effect of only 31.5% (single PTT), which was further proved by the more severe photothermal ablation in vitro and in vivo upon 808 nm laser irradiation. Conclusion: Such smart nanococktail nanomaterials could be recognized as a promising photothermal nanotheranostics for image-guided cancer treatment.
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