期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 496, 期 -, 页码 243-253出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2017.02.036
关键词
Langmuir monolayers; Drug-carriers composites; Dendrons; Cell culture
资金
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET-Argentina PIP) [112-20110101029]
- Agencia Nacional de Promocion Cientifica y Tecnologica (FONCYT-Argentina) [PICT 0415-2014, PICT-0654-2011]
- Secretaria de Ciencia y Tecnica
- DFG-CONICET [5055/2013]
Organic macromolecules with dendrimeric architectures are polymeric materials potentially useful as nanocarriers for therapeutic drugs. In this work, we evaluate a series of Newkome-type dendrons in Langmuir and Langmuir-Blodgett films as platforms capable of interacting with a potential antitumoral agent. The nanocomposite is proposed as model for the development of surface mediated drug delivery systems. We were successful in the formation and characterization of pure (dendrons) and composite (drug-dendron) stable and reproducible monolayers, and their transfer to solid substrates. A detailed study of topographic characteristics of the generated surfaces by atomic force microscopy was conducted. Furthermore, we probed dendron monolayer films as anchorage surfaces for mammalian cells. Normal cell attachment and proliferation on the surfaces were observed. No evident cytotoxic effects were detected, demonstrating the adequate biocompatibility of the surfaces. (C) 2017 Elsevier Inc. All rights reserved.
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