期刊
CEN CASE REPORTS
卷 9, 期 3, 页码 289-290出版社
SPRINGER JAPAN KK
DOI: 10.1007/s13730-020-00454-0
关键词
Thrombotic thrombocytopenic purpura; TTP; Acute kidney injury; Checkpoint inhibitor therapy
Dual checkpoint inhibitor therapy has known immune-related adverse events. However, checkpoint inhibitor-associated thrombotic thrombocytopenic purpura is very rarely reported. We present a case of a 70-year old man with advanced melanoma, presenting with severe thrombocytopenia, hemolytic anemia with schistocytes and suppressed ADAMTS-13 activity by ADAMTS-13 inhibitors. We discuss differential diagnoses and speculated mechanisms of this obviously therapy-related adverse event, which should be considered by clinicians prescribing these drugs.
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