期刊
CLINICAL JOURNAL OF GASTROENTEROLOGY
卷 13, 期 4, 页码 506-511出版社
SPRINGER JAPAN KK
DOI: 10.1007/s12328-020-01094-8
关键词
Gastric carcinoma; Epstein-Barr virus; Helicobacter pylori; Eradication
资金
- Ministry of Education, Culture, Science and Technology of Japan [18K07974]
- Grants-in-Aid for Scientific Research [18K07974] Funding Source: KAKEN
Epstein-Barr virus-associated gastric carcinoma (EBVaGC) can develop in gastric mucosa affected by Helicobacter pylori (H. pylori)-induced atrophic gastritis. However, it is unclear whether EBVaGC can develop in gastric mucosa after successful eradication of H. pylori. We report 3 cases of EBVaGC discovered more than 5 years after successful eradication of H. pylori. All 3 cases are men with a history of smoking. The periods from successful eradication to development of EBVaGC were 18, 8, and 9 years, respectively. Their tumors were mainly depressed lesions located in the gastric corpus. Two patients had intramucosal cancer and the other had advanced gastric cancer. Mucosal atrophy was present in the background gastric mucosa of all of three, and the anti-H. pylori antibody titer in each patient had fallen to < 3 U/mL. These cases indicate that EBVaGC can occur after successful eradication of H. pylori.
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