期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 505, 期 -, 页码 1055-1064出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2017.06.102
关键词
Nanostars; Nanoparticles; Gold; Cell internalization
资金
- Italian Ministry of Instruction, University and Research (MIUR)
- PRIN [20109PLMH2]
- University of Pavia
- CIRCMSB (Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici)
The synthesis of large pentatwinned five-branched gold nanostars (GNS) has been modified so to obtain overall dimensions shrunk to 60% and a lower branches aspect ratio, leading to a dramatic blue shift of their two near-infrared (NIR) localized surface plasmon resonances (LSPR) absorptions but still maintaining one LSPR in the biotransparent NIR range. The interactions of polyethylene glycol (PEG) coated large and shrunk GNS with SH-SY5Y cells revealed that the large ones (DCI - diameter of the circumference in which GNS can be inscribed = 76 nm) are internalized more efficiently than the shrunk ones (DCI = 46 nm), correlating with a decreased cells surviving fraction. (C) 2017 Elsevier Inc. All rights reserved.
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