期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 488, 期 -, 页码 303-308出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2016.11.015
关键词
Resveratrol; Soy protein isolate; Nanocomplex; Colloidal stability; Solubility; Control release
资金
- National Health and Medical Research Council [1107836, 1071796, 1059726]
- University of Queensland
- Mater Foundation
- Australian Government
- National Health and Medical Research Council of Australia [1107836, 1071796, 1059726] Funding Source: NHMRC
The polyphenolic compound resveratrol has received significant attention due to its many pharmacological actions such as anti-cancer, anti-inflammatory, antioxidant and antimicrobial activities. However, poor solubility and stability are major impediments for resveratrol's clinical effectiveness. In this work we have encapsulated resveratrol into soy protein isolate nanoparticles using a simple rotary evaporation technique. Resveratrol-loaded nanoparticles were around 100 nm in diameter and negatively charged. Nano-encapsulated resveratrol was found to be in amorphous form and showed more than two times higher solubility with significantly increased dissolution when compared to free resveratrol. Finally, an in-vitro NF-kappa B inhibition assay revealed that encapsulated resveratrol was stable and retained bioactivity. This new formulation of resveratrol has the potential to boost the clinical effectiveness of this drug and could be utilised for other poorly soluble hydrophobic drugs. (C) 2016 Elsevier Inc. All rights reserved.
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