期刊
JACC-BASIC TO TRANSLATIONAL SCIENCE
卷 5, 期 2, 页码 169-179出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2019.11.007
关键词
denervation; heart; hypertension; kidney; SGLT2; sympathetic nervous system
资金
- Royal Perth Hospital Research Foundation
- Diabetes Research Western Australia
- National Health and Medical Research Council
- Boehringer Ingelheim
- Medtronic
- Abbott
- Novartis
- Servier
- Pfizer
Recent clinical trial data suggest a cardiorenal protective effect of sodium glucose cotransporter 2 (SGLT2) inhibition. We demonstrate that chemical denervation in neurogenic hypertensive Schlager (BPH/2J) mice reduced blood pressure, improved glucose homeostasis, and reduced renal SGLT2 protein expression. Inhibition of SGLT2 prevented weight gain, reduced blood pressure, significantly reduced elevations of tyrosine hydroxytase and norepinephrine, and protects against endothelial dysfunction. These findings provide evidence for significant crosstalk between activation of the sympathetic nervous system and SGLT2 regulation and possible ancillary effects on endothelial function, which may contribute to the observed cardiorenal protective effects of SGLT2 inhibition. (C) 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
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