期刊
TRENDS IN CHEMISTRY
卷 2, 期 2, 页码 123-136出版社
CELL PRESS
DOI: 10.1016/j.trechm.2019.07.002
关键词
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资金
- Cancer Research UK [C14303/A17197]
- Cancer Research UK programme [C9681/A18618]
- EU H2020 Framework Programme (H2020-MSCA-IF-2016) [747297-QAPs]
- Welcome Trust [099232/Z/12/Z]
- Wellcome Trust [099232/Z/12/Z] Funding Source: Wellcome Trust
Guanine-rich DNA sequences can fold into four-stranded, noncanonical secondary structures called G-quadruplexes (G4s). G4s were initially considered a structural curiosity, but recent evidence suggests their involvement in key genome functions such as transcription, replication, genome stability, and epigenetic regulation, together with numerous connections to cancer biology. Collectively, these advances have stimulated research probing G4 mechanisms and consequent opportunities for therapeutic intervention. Here, we provide a perspective on the structure and function of G4s with an emphasis on key molecules and methodological advances that enable the study of G4 structures in human cells. We also critically examine recent mechanistic insights into G4 biology and protein interaction partners and highlight opportunities for drug discovery.
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