4.7 Review

Distribution and storage of inflammatory memory in barrier tissues

期刊

NATURE REVIEWS IMMUNOLOGY
卷 20, 期 5, 页码 308-320

出版社

NATURE RESEARCH
DOI: 10.1038/s41577-019-0263-z

关键词

-

资金

  1. Damon Runyon Cancer Research Foundation [DRG-2274-16]
  2. Richard and Susan Smith Family Foundation
  3. Searle Scholars Program
  4. Beckman Young Investigator Program
  5. Pew-Stewart Scholars Program for Cancer Research
  6. Sloan Fellowship in Chemistry
  7. US National Institutes of Health [1DP2GM119419, 2U19AI089992, 2R01HL095791, 1U54CA217377, 2P01AI039671, 5U24AI118672, 2RM1HG006193, 1U2CCA23319501, 1R01AI138546, 1R01HL134539, 1R01DA046277]
  8. US Food and Drug Administration [HHSF223201810172C]
  9. Bill and Melinda Gates Foundation

向作者/读者索取更多资源

In this Review, the authors encourage us to extend our concept of memory by considering the diverse cell types within a barrier tissue. They propose that any long-term resident or essential tissue cell type can store memory of previous immune events and cooperate in memory recall. Memories of previous immune events enable barrier tissues to rapidly recall distinct environmental exposures. To effectively inform future responses, these past experiences can be stored in cell types that are long-term residents or essential constituents of tissues. There is an emerging understanding that, in addition to antigen-specific immune cells, diverse haematopoietic, stromal, parenchymal and neuronal cell types can store inflammatory memory. Here, we explore the impact of previous immune activity on various cell lineages with the goal of presenting a unified view of inflammatory memory to environmental exposures (such as allergens, antigens, noxious agents and microorganisms) at barrier tissues. We propose that inflammatory memory is distributed across diverse cell types and stored through shifts in cell states, and we provide a framework to guide future experiments. This distribution and storage may promote adaptation or maladaptation in homeostatic, maintenance and disease settings - especially if the distribution of memory favours cellular cooperation during storage or recall.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据