期刊
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
卷 37, 期 2, 页码 231-238出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JCP.0000000000000666
关键词
extrapyramidal symptoms; movement disorders; epidemiology
资金
- Geestkracht programme of the Dutch Health Research Council (ZON-MW) [10-000-1001]
- Lundbeck
- AstraZeneca
- Eli Lilly
- Janssen Cilag
- Amsterdam: Academic Psychiatric Centre of the Academic Medical Center
- GGZ Ingeest
- Arkin
- Dijk en Duin
- GGZ Rivierduinen
- Erasmus Medical Centre
- GGZ Noord Holland Noord
- Maastricht University Medical Centre
- GGZ Eindhoven en de kempen
- GGZ Breburg
- GGZ Oost-Brabant
- Vincent van Gogh voor Geestelijke Gezondheid
- Mondriaan Zorggroep
- Prins Clauscentrum Sittard
- RIAGG Roermond
- Universitair Centrum Sint-Jozef Kortenberg
- CAPRI University of Antwerp
- PC Ziekeren Sint-Truiden
- PZ Sancta Maria Sint-Truiden
- GGZ Overpelt
- OPZ Rekem
- University Medical Center Groningen
- GGZ Friesland
- GGZ Drenthe
- Dimence
- Mediant
- GGNet Warnsveld
- Yulius Dordrecht
- Parnassia psycho-medical center (The Hague)
- University Medical Center Utrecht
- Altrecht
- GGZ Centraal
- Riagg Amersfoort
- Delta
Background Drug-related movement disorders (DRMDs) reduce quality of life and contribute to medication noncompliance of patients with psychotic disorders. Little is known about the epidemiology of DRMDs in relatively young patients a few years after onset of psychosis. This is an important period to study, as the impact of the antipsychotic treatment on the long-term potentiation of the neural pathways associated with psychotic disorders and DRMDs is still minimal. This study investigated the prevalence, incidence, persistence, and clinical correlates of DRMDs in patients during their first years after disease onset. Methods The Genetic Risk and Outcome of Psychosis study is a longitudinal study of 1120 relatively young patients with nonaffective psychosis and a mean age and illness duration of 27 and 4 years, respectively. The following drug-related movement disorders were assessed at baseline and at the 3-year follow-up: parkinsonism, akathisia, tardive dyskinesia, and tardive dystonia. We determined prevalence, incidence, and persistence and investigated clinical correlates at and over the baseline and follow-up assessment. Results Patients' mean age and illness duration at baseline were 27.1 and 4.3 years, respectively. In 4 patients, 1 developed a DRMD over the 3-year study period. Prevalence, incidence, and persistence rates were highest for parkinsonism (32%, 21%, and 53%) followed by akathisia (9%, 5%, and 17%) and tardive dyskinesia (4%, 3%, and 20%). Significant associations were found between DRMDs and the patients' age, IQ, and psychopathology. Conclusions The prevalence, persistence, and incidence of DRMDs in this sample were high despite the relatively young age, recent onset of the disorder, and treatment primarily with second-generation antipsychotics. These findings emphasize that screening, diagnosis, and treatment of DRMDs are still important.
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