期刊
JOURNAL OF CLINICAL PHARMACOLOGY
卷 58, 期 1, 页码 7-24出版社
WILEY
DOI: 10.1002/jcph.1028
关键词
Immunopharmacology; Oncology; Drug Information; Molecular Biology; Pharmaceutical R & D
资金
- Medical Scientist Training Program at Emory University School of Medicine
- National Institutes of Health (NIH) [R01CA207619]
- Department of Defense [CA150523]
- NIH [K99CA197801, R01CA208253-01, R01CA74364]
- Department of Veterans Affairs [5I01BX001922]
- Melanoma Research Foundation
- Skin Cancer and Melanoma Fund of the Winship Cancer Institute
- Melanoma Innovation Fund of the Winship Cancer Institute
- NATIONAL CANCER INSTITUTE [R01CA188523, R01CA207619, R01CA208253] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008169] Funding Source: NIH RePORTER
- Veterans Affairs [I01BX001922] Funding Source: NIH RePORTER
Two pharmacologic approaches that are currently at the forefront of treating advanced cancer are those that center on disrupting critical growth/survival signaling pathways within tumor cells (commonly referred to as targeted therapies) and those that center on enhancing the capacity of a patient's immune system to mount an antitumor response (immunotherapy). Maximizing responses to both of these approaches requires an understanding of the oncogenic events present in a given patient's tumor and the nature of the tumor-immune microenvironment. Although these 2 modalities were developed and initially used independently, combination regimens are now being tested in clinical trials, underscoring the need to understand how targeted therapies influence immunologic events. Translational studies and preclinical models have demonstrated that targeted therapies can influence immune cell trafficking, the production of and response to chemokines and cytokines, antigen presentation, and other processes relevant to antitumor immunity and immune homeostasis. Moreover, because these and other effects of targeted therapies occur in nonmalignant cells, targeted therapies are being evaluated for use in applications outside of oncology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据