期刊
JOURNAL OF CLINICAL PERIODONTOLOGY
卷 44, 期 7, 页码 717-728出版社
WILEY
DOI: 10.1111/jcpe.12744
关键词
antimicrobial photodynamic therapy; chronic periodontitis; microbiology; photosensitizing; surgical treatment
资金
- Sao Paulo Research Foundation - FAPESP [14/09801-9]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [14/09801-9] Funding Source: FAPESP
AimThis randomized controlled clinical trial evaluated the effects of an adjunctive single application of antimicrobial photodynamic therapy (aPDT) in Surgical Periodontal Treatment (ST) in patients with severe chronic periodontitis (SCP). Material and MethodsIn a split-mouth design, 20 patients with SCP were treated with aPDT+ST (Test Group, TG) or ST only (Control Group, CG). aPDT was applied in a single episode, using a diode laser and a phenothiazine photosensitizer. All patients were monitored until 90days after surgical therapy. Levels of 40 subgingival species were measured by checkerboard DNA-DNA hybridization at baseline, 60 and 150days. Clinical and microbiological parameters were evaluated. ResultsIn deep periodontal pockets depth (PPD 5mm), Test Group presented a significantly higher decrease in PPD than Control Group at 90days after surgical therapy (p<.05). Test Group also demonstrated significantly less periodontal pathogens of red complex (Treponema denticola) (p<.05). ConclusionA single episode of aPDT used in adjunct to open flap debridement of the root surface in the surgical treatment of SCP: i) significantly improved clinical periodontal parameters; ii) eliminates periodontal pathogens of the red complex more effectively (NCT02734784).
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