期刊
CHEMICAL SCIENCE
卷 11, 期 3, 页码 618-630出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9sc05460j
关键词
-
资金
- Nanyang Technological University [NTU-SUG: M4081627.120]
- Singapore Ministry of Education, Academic Research Fund Tier 1 [RG133/15 M4011559, 2017-T1-002-134-RG147/17]
- Singapore Ministry of Education, Academic Research Fund Tier 2 [MOE2016-T2-1-098]
- Northwest University
- National Natural Science Foundation of China [21904105]
Theranostics that integrates diagnosis and treatment modalities has attracted great attention due to its abilities of personalized therapy and real-time monitoring of therapeutic outcome. Such a theranostic paradigm requires agents to simultaneously possess the capabilities of targeting, imaging, and treatment. Activatable molecular agents (AMAs) are promising for cancer theranostics, as they show a higher signal-to-noise ratio (SNR), real-time detection of cancer-associated biomarkers, lower normal tissue toxicity, and a higher therapeutic effect. This perspective summarizes the recent advancements of AMAs, which include imaging-guided chemotherapy, imaging-guided photodynamic therapy, and imaging-guided photothermal therapy. The molecular design principles, theranostic mechanisms, and biomedical applications of AMAs are described, followed by a discussion of potential challenges of AMAs in cancer theranostics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据