4.8 Article

Activatable molecular agents for cancer theranostics

期刊

CHEMICAL SCIENCE
卷 11, 期 3, 页码 618-630

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9sc05460j

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资金

  1. Nanyang Technological University [NTU-SUG: M4081627.120]
  2. Singapore Ministry of Education, Academic Research Fund Tier 1 [RG133/15 M4011559, 2017-T1-002-134-RG147/17]
  3. Singapore Ministry of Education, Academic Research Fund Tier 2 [MOE2016-T2-1-098]
  4. Northwest University
  5. National Natural Science Foundation of China [21904105]

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Theranostics that integrates diagnosis and treatment modalities has attracted great attention due to its abilities of personalized therapy and real-time monitoring of therapeutic outcome. Such a theranostic paradigm requires agents to simultaneously possess the capabilities of targeting, imaging, and treatment. Activatable molecular agents (AMAs) are promising for cancer theranostics, as they show a higher signal-to-noise ratio (SNR), real-time detection of cancer-associated biomarkers, lower normal tissue toxicity, and a higher therapeutic effect. This perspective summarizes the recent advancements of AMAs, which include imaging-guided chemotherapy, imaging-guided photodynamic therapy, and imaging-guided photothermal therapy. The molecular design principles, theranostic mechanisms, and biomedical applications of AMAs are described, followed by a discussion of potential challenges of AMAs in cancer theranostics.

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