期刊
JOURNAL OF CLINICAL PATHOLOGY
卷 70, 期 9, 页码 798-802出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jclinpath-2017-204370
关键词
-
类别
Non-small cell lung carcinoma harbouring epidermal growth factor receptor (EGFR) mutation, usually progress after an initial response to tyrosine-kinase inhibitors (TKI). Liquid biopsy enables with a simple blood draw the accurate detection of EGFR p. T790M mutation, the most common resistance mechanism, avoiding the more invasive tissue re-biopsy. However, in a subset of cases, resistance mechanisms are more complex featuring both genetic and morphological changes. Here we report the case of a 67 years-old woman, affected by an EGFR mutated lung adenocarcinoma and treated by TKI. At disease progression, the patient developed a morphological transition to squamous cell carcinoma in association to the arising of a PIK3CA p. E542K mutant subclone. This case illustrates that, even in the liquid biopsy era, cytology can have still a role by providing an overall assessment of both morphology and genetic TKI resistance mechanisms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据