期刊
BIOMATERIALS SCIENCE
卷 8, 期 2, 页码 739-745出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9bm01726g
关键词
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资金
- National Natural Science Foundation of China [21574038, 21774031, 21861162010]
- Natural Science Foundation of Shanghai [18ZR1410300]
- National Key Research and Development Program of China [2016YFC1100401]
- Eastern Scholar Professorship from Shanghai Local Government [TP2014034]
- national special fund for State Key Laboratory of Bioreactor Engineering
- Fundamental Research Funds for the Central Universities [22221818014, 50321041917001]
- Key Laboratory of Specially Functional Polymeric Materials and Related Technology (ECUST) of Ministry of Education
- Shanghai Municipal Science and Technology Commission [17441901000]
- Medical Cross Fund Project of SJTU [YG2019ZDA17]
Multidrug resistant (MDR) Pseudomonas aeruginosa has caused serious nosocomial infections owing to its high intrinsic resistance and ease of acquiring resistance to common antibiotics. There is an urgent need to develop antimicrobial agents against MDR Pseudomonas aeruginosa. Here we report a 27-mer peptide polymer 90 : 10 DLL : BLG, as a synthetic mimic of a host defense peptide, that displayed potent in vitro and in vivo activities against multiple strains of clinically isolated MDR Pseudomonas aeruginosa, performing even better than antibiotics within our study. This peptide polymer also showed negligible hemolysis and low cytotoxicity, as well as quick bacterial killing efficacy. The structural diversity of peptide polymers, their easy synthesis from lithium hexamethyldisilazide-initiated fast N-carboxyanhydride polymerization, and the excellent reproducibility of their chemical structure and biological profiles altogether suggested great potential for antimicrobial applications of peptide polymers as synthetic mimics of host defense peptides.
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