期刊
GENOME BIOLOGY
卷 21, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13059-020-1926-6
关键词
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资金
- IAS Fellowship for external researchers at the University of Amsterdam
- Helmholtz Incubator [Sparse2Big ZT-I-0007]
- Klaus Tschira Foundation
- National Science Foundation [NSF: DBI-1564899, CCF-1619110]
- National Institutes of Health [NIH: 1R01EB025022-01]
- Oncode Institute [220-H72009 KWF/2016-1/10158]
- Netherlands Organisation for Scientific Research (NWO: Vidi grant) [864.14.004]
- NSF [CCF-1053753, 1564936]
- NIH [1R01EB025022, R01HG007069]
- Chan Zuckerberg Initiative (CZI) Donor-Advised Fund (DAF), an advised fund of the Silicon Valley Community Foundation [2018-182608]
- University of Edinburgh
- Alan Turing Institute (EPSRC grant) [EP/N510129/1]
- National Health and Medical Research Council of Australia [GNT1112681, GNT1162829]
- Katharina Hardt Stiftung
- Deutsche Krebshilfe (national Network Genomic Medicine Lung Cancer, nNGM)
- German Research Foundation (DFG: Collaborative Research Centre 1243)
- BMBF [01IS18036A, 01IS18053A, 01ZX1711A]
- Marie Sklodowska-Curie grant [642691]
- European Molecular Biology Laboratory (EMBL)
- Cancer Research UK [CRUK: C9545/A29580]
- NWO (Veni grant) [016.173.076]
- EMBL
- SystemsX.ch (RTD Grant) [2013/150]
- Canadian Institutes of Health Research (CIHR)
- Canadian Statistical Sciences Institute (CANSSI)
- UBC Data Science Institute
- NIH -National Human Genome Research Institute (NHGRI) Career Development Award [R00HG008399]
- Genomic Innovator Award [R35HG010717]
- CZI DAF [2018-182734, 182835, 2018-182828, 182891, 193161, 356-01]
- NWO (Vidi grant) [864.14.004, 639.072.309, 639.072.715]
- Swiss National Science Foundation [310030 175841, CRSII5 177208]
- University Research Priority Program Evolution in Action at the University of Zurich
- ERC [609883]
- BC Cancer Foundation
- CIHR
- Canadian Cancer Society (CCS) Research Institute (CCSRI)
- Terry Fox Research Institute (TFRI)
- CRUK
- NIH NHGRI [R00HG009007]
- Susan G. Komen scholar award
- Nicholls Biondi Endowed Chair in Computational Oncology
- Cycle for Survival Benefitting Memorial Sloan Kettering Cancer Center
- TFRI
- CCS
- Award of a Research Fellowships for the Promotion of Scientific Cooperation at the Helmholtz-Centre for Infection Research
- Swiss National Science Foundation (SNF) [310030_175841] Funding Source: Swiss National Science Foundation (SNF)
- Marie Curie Actions (MSCA) [642691] Funding Source: Marie Curie Actions (MSCA)
- European Research Council (ERC) [609883] Funding Source: European Research Council (ERC)
The recent boom in microfluidics and combinatorial indexing strategies, combined with low sequencing costs, has empowered single-cell sequencing technology. Thousands-or even millions-of cells analyzed in a single experiment amount to a data revolution in single-cell biology and pose unique data science problems. Here, we outline eleven challenges that will be central to bringing this emerging field of single-cell data science forward. For each challenge, we highlight motivating research questions, review prior work, and formulate open problems. This compendium is for established researchers, newcomers, and students alike, highlighting interesting and rewarding problems for the coming years.
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