期刊
GREEN CHEMISTRY
卷 22, 期 2, 页码 327-331出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9gc03351c
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资金
- project Development and application of QM/MM technologies for the design of light responsive proteins or protein-mimics based on rhodopsin architecture within the program Dipartimenti di Eccellenza - 2018-2022 - MIUR (Rome, Italy)
A simple and environmentally benign procedure for the synthesis of secondary amines in water has been developed. Combining Ru-3(CO)(12), tetraphenylcyclopentadienone and a small quantity of TGPS-750-M surfactant, primary and secondary alcohols were alkylated at N employing equimolar amounts of aromatic amines in water. The reaction occurs under microwave (MW) dielectric heating with high conversion and high yield. When required, the use of biomass-derived 2-MeTHF or GVL as a co-solvent is possible. Under the influence of MWs, a Ru nanoparticle-nanomicelle combination was formed acting as an effective and recyclable catalyst. This protocol was also employed for in water cyclisation to synthesise biologically relevant pyrrolobenzodiazepines (PBDs).
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