期刊
GREEN CHEMISTRY
卷 22, 期 2, 页码 322-326出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9gc03841h
关键词
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资金
- National Key Research and Development Program of China [2017YFD0200500]
- NSFC [21971065, 21722202, 21672069, 21871089]
- S&TCSM of Shanghai [18JC1415600]
- Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
- National Program for Support of Top-notch Young Professionals
A highly efficient one-step synthesis of alkyl-alkyl and aryl-alkyl sulfones with a facile combination of halides, sulfur dioxide surrogates and phosphate esters is described. When thiourea dioxide was employed as a reductive sulfur dioxide surrogate, alkyl-alkyl sulfones were obtained under transition metal free conditions. Aryl-alkyl sulfones were obtained with an extremely low catalytic loading (0.2 mol%) via altering the mask of sulfur dioxide surrogates to sodium dithionite. A phosphate ester was employed as a stable and readily available alkyl source. Notably, this protocol has been applied to the late-stage modification of natural products and bioactive molecules.
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