期刊
NATURAL PRODUCT REPORTS
卷 37, 期 1, 页码 6-16出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8np00027a
关键词
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资金
- National Key Research and Development Program [2016YFD0400105]
- National Natural Science Foundation of China [31861133004]
- Construction of the Registry and Database of Bioparts for Synthetic Biology of the Chinese Academy of Sciences [ZSYS-016]
- State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences [GTZK201802]
- Peking Union Medical College [GTZK201802]
Covering: Up to March 2019 Secondary metabolites (SMs) are chemical entities produced by organisms in response to environmental stimuli and as a defense against biological warfare. The production of SMs is controlled by a hierarchical regulatory network involving core factors that orchestrate transcriptional activation of SM gene clusters. In the past few years, significant achievements have been made in the discovery of novel fungal natural products by genetic manipulations of various types of transcriptional regulators. In this review, we summarized the representative regulators for the activation of fungal secondary metabolism and focused on the strategies for the exploitation of these regulators and their application in finding novel structures.
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