期刊
ACS APPLIED BIO MATERIALS
卷 3, 期 2, 页码 920-934出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.9b00984
关键词
bovine serum albumin; bovine serum albumin methacryloyl; photocurable hydrogels; tunable properties; tissue engineering; three-dimensional scaffolds
资金
- National Research Foundation (NRF) Singapore Competitive Research Programme [NRF-CRP10-2012-070]
- Nanyang Technological University (NTU) -Interdisciplinary Graduate School (IGS)
- Zhejiang Provincial Natural Science Foundation of China [LGF19E030001]
- Wenzhou Medical University [QTJ17012]
- Wenzhou Institute of Biomaterial and Engineering University of CAS [WIUCASQD2019003]
Photopolymerization of protein-derived polymers functionalized with methacryloyl groups has been increasingly used to fabricate three-dimensional tissue constructs for biomedical applications because photocurable protein-based polymers (e.g., gelatin and collagen methacryloyl) feature spatial-temporal controllability of engineering complex constructs as well as inherent biological properties. Herein, we report photocurable albuminbased hydrogels. First, photocurable bovine serum albumin methacryloyl (BSA-MA) with different degrees of substitution (DM) was successfully synthesized in a precise manner, without substantially altering BSA native secondary structure. Resultant photocurable BSA-MA hydrogels exhibited tunable physio-biochemical properties over the swelling, degradation, and mechanical properties. Moreover, photo-cross-linked BSA-MA hydrogels provided a permissible environment to support cell viability and functionality both in two- and three-dimensional culture systems. Photocurable BSA-MA hydrogels may be used as a versatile platform for various bioapplications including tissue engineering and 3D bioprinting.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据