期刊
SOFT MATTER
卷 16, 期 4, 页码 983-989出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9sm01642b
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资金
- U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, Materials Science and Engineering Division
- NSF [DMR-1508249, DMR-0520547]
- Divisions of Chemistry (CHE), National Science Foundation [NSF/CHE-1834750]
- Division of Materials Research (DMR), National Science Foundation [NSF/CHE-1834750]
- DOE Office of Science [DE-AC02-06CH11357]
- Office of Biological & Environmental Research in the Department of Energy's Office of Science
- European Union's Horizon 2020 Research and Innovation Programme under the SINE2020 project [654000]
- NIST [DMR-1508249, 70NANB15H259]
- U.S. Department of Commerce [70NANB15H260]
The structure and dynamics of lipid membranes in the presence of extracellular macromolecules are critical for cell membrane functions and many pharmaceutical applications. The pathogen virulence-suppressing end-phosphorylated polyethylene glycol (PEG) triblock copolymer (Pi-ABAPEG) markedly changes the interactions with lipid vesicle membranes and prevents PEG-induced vesicle phase separation in contrast to the unphosphorylated copolymer (ABAPEG). Pi-ABAPEG weakly absorbs on the surface of lipid vesicle membranes and slightly changes the structure of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) unilamellar vesicles at 37 degrees C, as evidenced by small angle neutron scattering. X-ray reflectivity measurements confirm the weak adsorption of Pi-ABAPEG on DMPC monolayer, resulting in a more compact DMPC monolayer structure. Neutron spin-echo results show that the adsorption of Pi-ABAPEG on DMPC vesicle membranes increases the membrane bending modulus kappa.
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