期刊
JOURNAL OF CLINICAL LIPIDOLOGY
卷 11, 期 6, 页码 1421-1431出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacl.2017.08.018
关键词
Heart failure; Cardiac magnetic resonance imaging; Myocardial fibrosis; Epicardial fat
资金
- National Science Council of the Republic of China [NSC 102-2314-B-002-058-, 102-2314-B-002 -087- MY2]
- TVGH-NTUH Joint Research Program [VN104-01]
OBJECTIVES: The aim of this study was to characterize the characteristics of epicardial fat (EAT) in different stage heart failure (HF) patients and its relationship between cardiac fibrosis. BACKGROUND: EAT is visceral adipose tissue that possesses inflammatory properties. Inflammation and obesity are associated with cardiac fibrosis, but the relationship between cardiac fibrosis and EAT is unknown. METHODS: EAT volume was measured using cardiac magnetic resonance imaging (CMR) in 180 subjects: 58 patients with systolic HF, 63 patients with HF and preserved ejection fraction, and 59 patients without HF. CMR derived myocardial extracellular volume (ECV) was used for fibrosis quantification. RESULTS: Patients with systolic HF had significantly more EAT compared with patients with HF and preserved ejection fraction or the control group (patients without HF) (indexed EAT volume [mL/m(2)], 27.0 [22.7-31.6] vs 25.6 [21.4-31.2] and 24.2 [21.0-27.6], P < .05). The adjusted EAT amount was associated with ECV completely independent of age, hypertension, diabetes, etiology of HF, left ventricular ejection fraction, CMR-late gadolinium enhancement (LGE), left ventricular mass index, and left ventricular end-diastolic volume index (correlation coefficient: 0.49; 95% confidence interval: 0.12-0.86, P < .01). Increased CMR ECV was more associated with EAT in those with advanced age, male sex, LGE on magnetic resonance imaging-LGE images, and less left ventricular end-diastolic volume index. CONCLUSIONS: EAT volume is highly associated with CMR ECV independent of traditional risk factors and left ventricular mass or volume. Whether EAT plays a role in the long-term prognosis of HF requires future investigation. (C) 2017 National Lipid Association. All rights reserved.
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